As next generation enterprise applications are more data driven and more intelligent, advanced analytics and machine Learning bring great business value. Oracle In-Database machine learning moves the algorithms to database where the data is stored. In this session, we will discuss how Oracle In-database machine learning is provided in Oracle Database including Oracle Autonomous Database with scalability, simplicity and high performance. We will discuss how to build, evaluate and deploys machine learning models natively with large enterprise data using Oracle Machine Learning for SQL(OML4SQL) and Oracle Machine Learning for Python (OML4Py). This session will take some use cases as examples to show the process of machine learning: analyze and prepare data set; build and evaluate and apply machine learning model with Oracle Autonomous Databases environment. Some Oracle 21c new features such as AutoML will also be discussed.